Week 5 NFL odds, spreads, totals, betting lines, for all 16 games, including Buccaneers-Cowboys, Bears-Packers

This page may contain affiliate links. If you click a link and sign up, make a deposit, place a wager, or make a trade, we may earn a commission at no additional cost to you. The Week 5 NFL schedule is here, featuring pivotal matchups like Cowboys vs. Buccaneers, 49ers vs. Seahawks and Bills vs. Rams Oct 8, 2026 at 7:50 am ET • 2 min read The Dallas Cowboys are set to host the Tampa Bay Buccaneers to kick off the Week 5 NFL schedule on Thursday Night Football. According to the latest NFL odds, the Cowboys are favored by 9.5 points at home, while the over/under for total points scored is 47.5. Other notable Week 5 NFL spreads include Eagles vs. Jaguars (-6.5) in London, Raiders vs. Patriots (-3.5), Broncos vs. Chargers (+3.5), 49ers vs. Seahawks (-3) and Bills vs. Rams (-2.5). Bet on every Week 5 NFL game with the latest DraftKings promo code, where new users get $150 in bonus bets after making a $5 wager: Below you'll find the NFL betting odds for every Week 5 matchup. You can find the SportsLine Projection Model's NFL betting advice for Week 5 here. Trade $25+ at Kalshi using the best Kalshi promo code CBSSPORTS55 and get $55 as a sign-up bonus:** Odds provided by DraftKings are subject to change **Thursday, Oct. 8Dallas Cowboys vs. Tampa Bay Buccaneers Spread: Cowboys -9.5Moneyline: Cowboys (-476), Buccaneers (+380)Total: 47.5 Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:Sunday, Oct. 11Jacksonville Jaguars vs. Philadelphia Eagles Spread: Jaguars -6.5Moneyline: Jaguars (-275), Eagles (+240)Total: 42.5 Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:Green Bay Packers vs. Chicago Bears Spread: Bears -3Moneyline: Packers (+136), Bears (-142)Total: 45.5 Claim $200 in bonus bets with a $10 bet by signing up for bet365 Sportsbook with the bet365 bonus code CBSBET365:Tennessee Titans vs. Houston Texans Spread: Texans -7Moneyline: Titans (+275), Texans (-323)Total: 39.5 Claim the Caesars Sportsbook promo code CBSSPORTSBR250 here and get your bonuses:Miami Dolphins vs. Cincinnati Bengals Spread: Bengals -7.5Moneyline: Dolphins (+310), Bengals (-345)Total: 42.5 Bet on the NFL with the FanDuel promo code and get $250 in bonus bets:New England Patriots vs. Las Vegas Raiders Spread: Patriots -3.5Moneyline: Patriots (-192), Raiders (+176)Total: 45.5 Bet on NFL games with the latest DraftKings promo code and get $150 in bonus bets after making a $5 wager: New Orleans Saints vs. Minnesota Vikings Spread: Vikings -1.5Moneyline: Saints (+102), Vikings (-118)Total: 42.5 Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:New York Jets vs. Cleveland Browns Spread: Jets -2.5Moneyline: Jets (-128), Browns (+110)Total: 39.5 Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:Pittsburgh Steelers vs. Indianapolis Colts Spread: Steelers -2.5Moneyline: Steelers (-135), Colts (+116)Total: 44.5 Claim the Caesars Sportsbook promo code CBSSPORTSBR250 here and get your bonuses:Washington Commanders vs. New York Giants Spread: Commanders -3Moneyline: Commanders (-166), Giants (+154)Total: 43.5 Bet on the NFL with the FanDuel promo code and get $250 in bonus bets:Los Angeles Chargers vs. Denver Broncos Spread: Broncos -3.5Moneyline: Chargers (+156), Broncos (-185)Total: 42.5 Claim $200 in bonus bets with a $10 bet by signing up for bet365 Sportsbook with the bet365 bonus code CBSBET365:Arizona Cardinals vs. Detroit Lions Spread: Lions -4.5Moneyline: Cardinals (+198), Lions (-225)Total: 54.5 Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:Seattle Seahawks vs. San Francisco 49ers Spread: Seahawks -3Moneyline: Seahawks (-148), 49ers (+138)Total: 47Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:Atlanta Falcons vs. Baltimore RavensSpread: Falcons -2.5Moneyline: Falcons (-155), Ravens (+130)Total: 44Bet on the NFL with the FanDuel promo code and get $250 in bonus bets:Monday, Oct. 12Los Angeles Rams vs. Buffalo Bills Spread: Rams -2.5Moneyline: Rams (-152), Bills (+135)Total: 54.5 Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets: