Rakovina Therapeutics and Celvion Therapeutics Complete AI Analysis Identifying Priority Cancer Indications for Brain-Penetrant ATR Inhibitor Program

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Postmedia has not reviewed the content. by GlobeNewswire Rakovina Therapeutics and Celvion Therapeutics Complete AI Analysis Identifying Priority Cancer Indications for Brain-Penetrant ATR Inhibitor ProgramAuthor of the article:EMphora™ platform integrates clinical evidence and predictive modelling to help identify promising cancer patient populations and guide the next phase of researchTHIS CONTENT IS RESERVED FOR SUBSCRIBERS ONLYSubscribe now to read the latest news in your city and across Canada.Exclusive articles from Barbara Shecter, Joe O'Connor, Gabriel Friedman, and others.Daily content from Financial Times, the world's leading global business publication.Unlimited online access to read articles from Financial Post, National Post and 15 news sites across Canada with one account.National Post ePaper, an electronic replica of the print edition to view on any device, share and comment on.Daily puzzles, including the New York Times Crossword.SUBSCRIBE TO UNLOCK MORE ARTICLESSubscribe now to read the latest news in your city and across Canada.Exclusive articles from Barbara Shecter, Joe O'Connor, Gabriel Friedman and others.Daily content from Financial Times, the world's leading global business publication.Unlimited online access to read articles from Financial Post, National Post and 15 news sites across Canada with one account.National Post ePaper, an electronic replica of the print edition to view on any device, share and comment on.Daily puzzles, including the New York Times Crossword.REGISTER / SIGN IN TO UNLOCK MORE ARTICLESCreate an account or sign in to continue with your reading experience.Access articles from across Canada with one account.Share your thoughts and join the conversation in the comments.Enjoy additional articles per month.Get email updates from your favourite authors.THIS ARTICLE IS FREE TO READ REGISTER TO UNLOCK.Create an account or sign in to continue with your reading experience.Access articles from across Canada with one accountShare your thoughts and join the conversation in the commentsEnjoy additional articles per monthGet email updates from your favourite authorsSign In or Create an AccountVANCOUVER, British Columbia, Oct. 28, 2026 (GLOBE NEWSWIRE) — Rakovina Therapeutics Inc. (TSX-V: RKV) (FSE: 7JO0) (OTCMKTS: RKVTF), a biopharmaceutical company advancing innovative cancer therapies through AI-powered drug discovery, and Boston-based Celvion Therapeutics (“Celvion”), today announced the completion of the first analysis in their collaboration using Celvion’s EMphora™ artificial intelligence platform to evaluate potential treatment strategies for Rakovina’s ATR inhibitor program.This advertisement has not loaded yet, but your article continues below.The analysis identified two priority cancer indications for a second, in-depth analysis. The findings provide a focused framework for determining which treatment strategies warrant further investigation as Rakovina advances development of its ATR inhibitor designed to cross the blood-brain barrier.Get the latest headlines, breaking news and columns.By signing up you consent to receive the above newsletter from Postmedia Network Inc.A welcome email is on its way. If you don't see it, please check your junk folder.The next issue of Top Stories will soon be in your inbox.We encountered an issue signing you up. Please try againCelvion’s EMphora™ platform leverages insights from completed clinical trials to evaluate novel therapeutic strategies and treatment combinations that have yet to be clinically investigated. By integrating predictive modelling with established clinical evidence and comparative target analyses, the platform provides a systematic framework for assessing therapeutic potential, prioritizing promising hypotheses, and identifying areas of uncertainty that warrant further investigation.The initial analysis evaluated ATR inhibition alone and in combination with 34 potential treatment partners across eight cancer types: non-small cell lung cancer, breast cancer, melanoma, small cell lung cancer, renal cell carcinoma, glioblastoma, lower-grade glioma and pediatric central nervous system tumours.This advertisement has not loaded yet, but your article continues below.The gains from adding ATR inhibition were concentrated in specific tumour types and therapeutic combinations, helping prioritize subsequent preclinical evaluation and development strategies.“Our collaboration with Celvion is an exciting example of how complementary AI capabilities can help sharpen the questions we ask in drug discovery,” said Dr. Mads Daugaard, President and Chief Scientific Officer of Rakovina Therapeutics. “The initial analysis gives us a more focused framework for investigating our ATR inhibitor program, particularly in areas of significant unmet medical need. Just as importantly, it helps us identify which hypotheses deserve a closer look and which require a more cautious assessment. Our next step is to determine experimentally whether the distinctive properties we are pursuing can translate into meaningful therapeutic potential.”“The initial findings show why potential drug combinations need to be evaluated in context: a mechanism does not deliver value in every cancer,” said Mi Yang, Chief Executive Officer of Celvion Therapeutics. “By integrating clinical outcomes with preclinical evidence, EMphora is designed to help drug developers identify and prioritize hypotheses that merit further investigation.”This advertisement has not loaded yet.This advertisement has not loaded yet, but your article continues below.By prioritizing targets, combinations and cancer settings before larger budgets are committed to chemical synthesis and laboratory testing, AI can help direct time and capital toward the most promising opportunities and support a more efficient approach to early-stage research.The next phase of work will explore the leading hypotheses in greater depth, including whether the intended brain-penetrant properties of Rakovina’s ATR inhibitor could address limitations encountered with earlier ATR inhibitors. Brain exposure and tolerability will be important considerations as the program advances.While the findings remain exploratory and computational, this approach demonstrates how AI can bridge drug discovery and clinical evidence, identifying new avenues for further investigation to determine whether predictions can translate into therapeutic potential.About Celvion Therapeutics, Inc.Celvion Therapeutics is a Boston-based AI company predicting effective drug combinations for solid tumours. Its EMphora™ platform learns from clinical-trial outcomes and preclinical evidence to prioritize combination strategies across small molecules, antibodies and bispecifics. Drug developers often study clinical outcomes and laboratory biology in separate teams; EMphora connects the two to help identify which combinations, patient populations and treatment settings warrant further investigation. Further information may be found at www.celviontx.com.This advertisement has not loaded yet, but your article continues below.About Rakovina Therapeutics Inc.Rakovina Therapeutics is a biopharmaceutical research company focused on the development of innovative cancer treatments. Our work is based on unique technologies for targeting the DNA-damage response powered by Artificial Intelligence (AI). By using AI, we can review and optimize drug candidates at a much greater pace than ever before.The Company has established a pipeline of distinctive DNA-damage response inhibitors with the goal of advancing one or more drug candidates into human clinical trials in collaboration with pharmaceutical partners. Further information may be found at www.rakovinatherapeutics.com.For Further Information Contact:Rakovina Therapeutics Inc.Kim OishiCEOkim.oishi@rakovinatherapeutics.comMark MitchellCommunicationsIR@rakovinatherapeutics.comCelvion Therapeutics Inc.Mi YangCEOmiyang@celviontx.comNeither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSXV) accepts responsibility for the adequacy or accuracy of this release.This advertisement has not loaded yet, but your article continues below.Notice Regarding Rakovina Therapeutics Forward-Looking Statements:This release includes forward-looking statements regarding the Company and its business, which may include, but are not limited to, statements with respect to the proposed business plan of the Company and other statements. Often, but not always, forward-looking statements can be identified by the use of words such as “plans,” “is expected,” “expects,” “scheduled,” “intends,” “contemplates,” “anticipates,” “believes,” “proposes” or variations (including negative variations) of such words and phrases, or statements that certain actions, events or results “may,” “could,” “would,” “might” or “will” be taken, occur or be achieved. Such statements are based on the current expectations of the Company’s management. The forward-looking events and circumstances discussed in this release may not occur by certain specified dates or at all and could differ materially as a result of known and unknown risk factors and uncertainties affecting the Company, including risks regarding the biopharmaceutical industry, economic factors, regulatory factors, the equity markets generally, and risks associated with growth and competition.This advertisement has not loaded yet.This advertisement has not loaded yet, but your article continues below.Although the Company has attempted to identify important factors that could cause actual actions, events or results to differ materially from those described in forward-looking statements, there may be other factors that cause actions, events or results to differ from those anticipated, estimated or intended. No forward-looking statement can be guaranteed. Except as required by applicable securities laws, forward-looking statements speak only as of the date on which they are made, and the Company undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise. Readers are referred to the Company’s most recent filings on SEDAR+ for a more complete discussion of applicable risk factors and their potential effects. Copies may be accessed through the Company’s profile page at www.sedarplus.ca.This advertisement has not loaded yet.Notice for the Postmedia NetworkThis website uses cookies to personalize your content (including ads), and allows us to analyze our traffic. Read more about cookies here. By continuing to use our site, you agree to our Terms of Use and Privacy Policy.