Christina Applegate reveals it takes her 10 minutes to get out of bed after going public with MS misdiagnosis

Christina Applegate offered a harrowing account of the 'excruciating' symptoms she is still suffering after learning she was misdiagnosed with multiple sclerosis (MS).Applegate, 54, announced she had MS in the summer of 2021 and subsequently began hosting the Messy podcast with The Sopranos star Jamie-Lynn Sigler, with the pair discussing their respective battles with the debilitating illness.Last week, Applegate tearfully disclosed on the show that her doctor recently informed her she does not in fact have MS.She explained that her health had not 'gotten better' and had instead 'gotten worse,' such that she was 'back at square one where I don't know what's going on with me.'Now, she has shared the details of her continuing physical problems, revealing the time and effort she has to expend just to leave her bed.'I actually timed it today. It took me 10 minutes to be able to move off my pillow and get out of the bed and stand up, at which point I almost couldn't walk to the bathroom,' Applegate said on the latest episode of Messy. Christina Applegate offered a harrowing account of the 'excruciating' symptoms she is still battling after learning she was misdiagnosed with multiple sclerosis (MS); pictured 2023 'And now I have a walker sitting next to my bed because of what's going on. I don't know what's going on. This is what I'm still living with. And I never had that before. I was able to sit up and stuff,' she added.'So this is what I said when things are getting worse or they're just new. Something new is happening. So it took 10 minutes just to sit my head up, just to move without excruciating pain and weakness.' On an episode of her podcast last week, Applegate tearfully recounted the moment her doctor told her she was not suffering from MS. 'She came into my room and said, "Congratulations, you don’t have MS”,' said Applegate 'I was, like, not happy at all. Everybody else was so happy.'You don’t get misdiagnosed and then all of a sudden I’m better. I haven’t gotten better, Jamie! If anything, I’ve gotten worse. So I’m back at square one where I don’t know what’s going on with me. 'And that’s going to be an online investigation that my doctors are going to be getting into just to find out what has been going on since 2021, why did this happen?'MS is a condition in which the immune system attacks the body and causes nerve damage to the brain and spinal cord.It is an incurable, lifelong condition. Symptoms can be mild in some, and in others more extreme causing severe disability.Symptoms include fatigue, difficulty walking, vision problems, bladder problems, numbness or tingling, muscle stiffness and spasms, problems with balance and co-ordination, and problems with thinking, learning and planning. Last week, Applegate tearfully disclosed on the show that her doctor recently informed her she does not in fact have MS Applegate, who has relied on a wheelchair and cane for years, and been forced to step away from her stellar acting career, said: 'I’ve gone through a great depression because of it.' Pictured in 2022Applegate, who has relied on a wheelchair and cane for years, and been forced to step away from her stellar acting career, said: 'I’ve gone through a great depression because of it. 'But I lost everything. I lost my job. I lost - I’m sorry. What do you say to someone who’s been living with this for six years - God, I’m so sorry - because it stopped my life. 'I still have to use wheelchairs when I go to the doctor’s office. I can’t walk from the car to the room. I’m still in this. Nothing magical happened when she said, "You don’t have MS." Nothing magical happened.'It’s weird because I feel like I let everybody down, It’s this weird feeling because I became this - you and I, the poster children for MS. 'And everything I was doing. I had a reason. I had a f***ing reason as to why my day sucked every day. 'And now I don’t have a reason and it’s very unnerving and it’s very confusing for me.'Applegate added the misdiagnosis is a 'mindf**k' and that she is still in 'a state of shock' as she seeks answers over the true nature of her illness. The Daily Mail has contacted representatives for Applegate for comment and has yet to hear back. 'You don’t get misdiagnosed and then all of a sudden I’m better. I haven’t gotten better, Jamie! If anything, I’ve gotten worse. So I’m back at square one where I don’t know what’s going on with me' said Applegate. Seen in April 2025 in LA She said: 'But I lost everything. I lost my job. I lost - I’m sorry. What do you say to someone who’s been living with this for six years - God, I’m so sorry - because it stopped my life.' Pictured as Amy Greene on Friends in 2002 with Courteney Cox and Matt Le Blanc Applegate is pictured with daughter Sadie, 15, in 2023 Applegate is pictured with her daughter, husband Martyn LeNoble and actress Nancy Priddy in 2022Applegate continued: 'I have every symptom of someone with MS. Every single one. Now, we both know that there are many things that mirror MS. Many different things.'I mean, I I'm sure people are saying like, "Crybaby, you don't have MS." You know, that's a good thing. But no, no, no.'I'm sitting here having slept all day yesterday feeling like absolute crap because of the heat. My legs aren't working. You know, all the same stuff is happening to me. And yet I have this thing of like, well, you don't have that, so you know, maybe you're faking it. you know, in my head I'm like, what can I be doing differently? 'What, you know, but this is what I'm sure a lot of people start thinking when they get their misdiagnosis is like, well, what have I done wrong? What what what am I doing?'Doctor Marwa Kaisey, associate professor with the Cedars-Sinai Medical Center department of neurology, gave insight into how MS can be misdiagnosed during an appearance on the podcast.Kaisey said: 'We don’t have one single test for MS. It’s not like we have something like a pregnancy test that says, Yes. You have it. No. You don’t. It’s a list of criteria.'Almost one in five of these people who’d been told they had MS, some for decades, didn’t actually have it. And a majority of them were on medication to treat their MS.'Applegate was reported to have gone back home in August after being hospitalized in Los Angeles since late March, TMZ reported. Selma Blair has waged a public battle with the debilitating condition - she is pictured with Applegate in 2002Sources told the publication that the actress, who was diagnosed with MS in 2021, was doing well since making the transition back to home life.There have been few details about why exactly she has been in the hospital for months on end.Applegate's first words to reassure her followers after her March hospitalization came in April, when she said on Instagram that she was getting 'stronger and better every day.'She posted a snap of her memoir You With The Sad Eyes, sharing she would be 'taking a moment to focus on her health.'Her post was captioned: 'Thank you for the outpouring of love and well wishes. Health issues are a constant for me, but I'm a strong chick and I'm getting stronger and better every day. I'm taking a moment to focus on my health, but I'll be back with more to say soon enough.'Sources previously told TMZ that the actress was admitted into a hospital late in March, but a reason hadn't been revealed.Applegate's representative told the Daily Mail: 'I have no comment on whether she is in the hospital or what her medical treatments are.'She's had a long history of complicated medical conditions that she has been refreshingly open about, as evidenced in her memoir and on her podcast.' Applegate is pictured in 2003 winning an Emmy for her guest role in Friends Earlier in February, Applegate shared that she is mainly confined to her bed due to her MS battle.During an interview with People at the time, the star explained how the pain has largely kept her in bed.However, she will make the effort to leave her bedroom for her teenage daughter Sadie, such as taking her to school.'I want to take her; it's my favorite thing to do. It's the only time we have together by ourselves,' the actress told the outlet.'I tell myself, "Just get her there safely and get home so you can get back into bed." And that's what I do.'Applegate further expressed: 'My life isn't wrapped up with a bow. People's lives, sorry for lack of a better term, f***ing suck sometimes. So I'm being as honest and raw as I possibly can.' Applegate rose to prominence as a child actress at the age of 15, while starring as Kelly Bundy in the Fox sitcom Married with Children, which ran from 1987–1997. Pictured with Katey Sagal, Ed O'Neill, and David FaustinoThe Dead To Me actress also reflected on her MS battle in an excerpt of her 2026 memoir You With The Sad Eyes that was published in The Guardian in March.'One of the worst side-effects of the illness is the exhaustion,' Applegate candidly wrote.'It feels as though I've been on a three‑day sleepless bender – and that's how I feel after a good night's sleep. Hence all the time I spend on and in bed, snuggled up against my heating pad.'She continued: 'On the back of that diagnosis and the symptoms I face, I no longer care what I say or how I come across or how it makes anyone feel. Applegate posted a photo of her canes back in 2022, and said needing help with walking is her 'new normal''I don't have patience for bulls*** any more, for things that are meaningless or merely "extra."'Applegate shared the news of her MS diagnosis on social media in August 2021.And in 2022 she posted a photo of her canes, and said needing help with walking is her 'new normal.'During an episode of her MeSsy podcast last year, the actress revealed that she had been hospitalized multiple times amid her MS battle. 'For three years since I was diagnosed, I've been in the hospital upwards of 30 times,' she told her co-host Jamie-Lynn Sigler, who is also battling the same disease.'That is unimaginable, okay? They've done every test known to man on me, put so much radiation into my body from CT scans to everything else.'When it came to penning her memoir, which was released on March 3, Applegate previously shared that she made the decision to pen the book when she was 'forced to slow down.'