Building a Biomedical GraphRAG Inference System: Comparing LLM-Only, Basic RAG, and GraphRAG Pipelines

Introduction As enterprise adoption of LLMs grows, inference costs, hallucinations, and retrieval inefficiencies are becoming major production challenges. Traditional vector-based Retrieval-Augmented Generation (RAG) improves grounding, but it still struggles with multi-hop reasoning and relationship-aware retrieval. For the TigerGraph GraphRAG Inference Hackathon, our team built a complete biomedical GraphRAG inference system that compares: • LLM-only inference • Basic RAG (Vector + LLM) •...