Week 4 NFL odds, spreads, totals, betting lines, for every game, including Texans-Cowboys, Raiders-Chiefs

This page may contain affiliate links. If you click a link and sign up, make a deposit, place a wager, or make a trade, we may earn a commission at no additional cost to you. The Week 4 NFL schedule is here, featuring pivotal matchups like Cowboys vs. Texans, Raiders vs. Chiefs and Lions vs. Panthers Oct 4, 2026 at 8:47 am ET • 3 min read Sunday's NFL schedule is packed with pivotal matchups, and now is the time to lock in your NFL betting picks. With matchups like Cowboys vs. Texans, Patriots vs. Bills, Chiefs vs. Raiders and Lions vs. Panthers on tap, finding value on the NFL odds board will be paramount. According to the latest NFL lines, the Texans are 2.5-point favorites at home against the Cowboys, despite Houston being winless through the first three weeks. Other notable Week 4 NFL spreads include Patriots vs. Bills (+7), Jaguars vs. Bengals (-2.5) and Raiders vs. Chiefs (-4.5). Bet on every Week 4 NFL game with the latest DraftKings promo code, where new users get $150 in bonus bets after making a $5 wager: Below you'll find the NFL betting odds for every Week 4 matchup. You can find the SportsLine Projection Model's NFL betting advice for Week 4 here. Trade $25+ at Kalshi using the best Kalshi promo code CBSSPORTS55 and get $55 as a sign-up bonus:** Odds provided by DraftKings are subject to change **Sunday, Oct. 4Indianapolis Colts vs. Washington Commanders Spread: Colts -3.5Moneyline: Colts (-187), Commanders (+155)Total: 47Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:New England Patriots vs. Buffalo BillsSpread: Bills -6.5Moneyline: Bills (-324), Patriots (+258)Total: 48.5Claim $200 in bonus bets with a $10 bet by signing up for bet365 Sportsbook with the bet365 bonus code CBSBET365:Tennessee Titans vs. Baltimore RavensSpread: Ravens -11.5Moneyline: Ravens (-714), Titans (+509)Total: 43.5Claim the Caesars Sportsbook promo code CBSSPORTSBR250 here and get your bonuses:New York Jets vs. Chicago BearsSpread: Bears -3Moneyline: Bears (-156), Jets (+132)Total: 43Bet on the NFL with the FanDuel promo code and get $250 in bonus bets:Jacksonville Jaguars vs. Cincinnati BengalsSpread: Bengals -2.5Moneyline: Bengals (-142), Jaguars (+120)Total: 51.5Bet on NFL games with the latest DraftKings promo code and get $150 in bonus bets after making a $5 wager: Dallas Cowboys vs. Houston TexansSpread: Texans -2.5Moneyline: Texans (-140), Cowboys (+119)Total: 47.5Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:Arizona Cardinals vs. New York GiantsSpread: Cardinals -1Moneyline: Cardinals (-112), Giants (-106)Total: 44.5Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:Los Angeles Rams vs. Philadelphia EaglesSpread: Rams -3Moneyline: Rams (-162), Eagles (+136)Total: 44Claim the Caesars Sportsbook promo code CBSSPORTSBR250 here and get your bonuses:Green Bay Packers vs. Tampa Bay BuccaneersSpread: Packers -4Moneyline: Packers (-188), Buccaneers (+157)Total: 39.5Bet on the NFL with the FanDuel promo code and get $250 in bonus bets:Miami Dolphins vs. Minnesota VikingsSpread: Vikings -10.5Moneyline: Vikings (-637), Dolphins (+469)Total: 38.5Claim $200 in bonus bets with a $10 bet by signing up for bet365 Sportsbook with the bet365 bonus code CBSBET365:Kansas City Chiefs vs. Las Vegas RaidersSpread: Chiefs -4.5Moneyline: Chiefs (-222), Raiders (+184)Total: 47.5Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:Denver Broncos vs. San Francisco 49ersSpread: 49ers -2.5Moneyline: 49ers (-149), Broncos (+125)Total: 46.5Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:Los Angeles Chargers vs. Seattle SeahawksSpread: Seahawks -7Moneyline: Seahawks (-334), Chargers (+268)Total: 43Bet on NFL games with the latest DraftKings promo code and get $150 in bonus bets after making a $5 wager: Detroit Lions vs. Carolina PanthersSpread: Lions -3.5Moneyline: Lions (-193), Panthers (+163)Total: 50.5Bet on the NFL with the FanDuel promo code and get $250 in bonus bets:Monday, Oct. 5Atlanta Falcons vs. New Orleans Saints Spread: Saints -2.5Moneyline: Saints (-151), Falcons (+127)Total: 48.5Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets: