Week 4 NFL odds, betting lines, spreads, totals, for every game, including Texans-Cowboys, Raiders-Chiefs

This page may contain affiliate links. If you click a link and sign up, make a deposit, place a wager, or make a trade, we may earn a commission at no additional cost to you. The Week 4 NFL schedule is here, featuring pivotal matchups like Cowboys vs. Texans, Raiders vs. Chiefs and Lions vs. Panthers Oct 3, 2026 at 11:13 am ET • 3 min read It's another loaded slate for NFL betting, with matchups like Cowboys vs. Texans, Rams vs. Eagles, Chiefs vs. Raiders and Lions vs. Panthers on tap. According to the latest Week 4 NFL odds, the Cowboys are 2.5-point underdogs against Houston, despite the Texans entering Sunday's showdown with a 0-3 record. Other notable Week 4 NFL lines include Rams vs. Eagles (+3), Chiefs vs. Raiders (+4.5) and Lions vs. Panthers (+3.5). The Rams will be without Aaron Donald against Philadelphia, who's already been ruled out with a back injury. Bet on every Week 4 NFL game with the latest DraftKings promo code, where new users get $150 in bonus bets after making a $5 wager: Below you'll find the NFL betting odds for every Week 4 matchup. You can find the SportsLine Projection Model's NFL betting advice for Week 4 here. Trade $25+ at Kalshi using the best Kalshi promo code CBSSPORTS55 and get $55 as a sign-up bonus:** Odds provided by DraftKings are subject to change **Sunday, Oct. 4Indianapolis Colts vs. Washington Commanders Spread: Colts -3.5Moneyline: Colts (-187), Commanders (+155)Total: 47Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:New England Patriots vs. Buffalo BillsSpread: Bills -6.5Moneyline: Bills (-324), Patriots (+258)Total: 48.5Claim $200 in bonus bets with a $10 bet by signing up for bet365 Sportsbook with the bet365 bonus code CBSBET365:Tennessee Titans vs. Baltimore RavensSpread: Ravens -11.5Moneyline: Ravens (-714), Titans (+509)Total: 43.5Claim the Caesars Sportsbook promo code CBSSPORTSBR250 here and get your bonuses:New York Jets vs. Chicago BearsSpread: Bears -3Moneyline: Bears (-156), Jets (+132)Total: 43Bet on the NFL with the FanDuel promo code and get $250 in bonus bets:Jacksonville Jaguars vs. Cincinnati BengalsSpread: Bengals -2.5Moneyline: Bengals (-142), Jaguars (+120)Total: 51.5Bet on NFL games with the latest DraftKings promo code and get $150 in bonus bets after making a $5 wager: Dallas Cowboys vs. Houston TexansSpread: Texans -2.5Moneyline: Texans (-140), Cowboys (+119)Total: 47.5Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:Arizona Cardinals vs. New York GiantsSpread: Cardinals -1Moneyline: Cardinals (-112), Giants (-106)Total: 44.5Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:Los Angeles Rams vs. Philadelphia EaglesSpread: Rams -3Moneyline: Rams (-162), Eagles (+136)Total: 44Claim the Caesars Sportsbook promo code CBSSPORTSBR250 here and get your bonuses:Green Bay Packers vs. Tampa Bay BuccaneersSpread: Packers -4Moneyline: Packers (-188), Buccaneers (+157)Total: 39.5Bet on the NFL with the FanDuel promo code and get $250 in bonus bets:Miami Dolphins vs. Minnesota VikingsSpread: Vikings -10.5Moneyline: Vikings (-637), Dolphins (+469)Total: 38.5Claim $200 in bonus bets with a $10 bet by signing up for bet365 Sportsbook with the bet365 bonus code CBSBET365:Kansas City Chiefs vs. Las Vegas RaidersSpread: Chiefs -4.5Moneyline: Chiefs (-222), Raiders (+184)Total: 47.5Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:Denver Broncos vs. San Francisco 49ersSpread: 49ers -2.5Moneyline: 49ers (-149), Broncos (+125)Total: 46.5Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:Los Angeles Chargers vs. Seattle SeahawksSpread: Seahawks -7Moneyline: Seahawks (-334), Chargers (+268)Total: 43Bet on NFL games with the latest DraftKings promo code and get $150 in bonus bets after making a $5 wager: Detroit Lions vs. Carolina PanthersSpread: Lions -3.5Moneyline: Lions (-193), Panthers (+163)Total: 50.5Bet on the NFL with the FanDuel promo code and get $250 in bonus bets:Monday, Oct. 5Atlanta Falcons vs. New Orleans Saints Spread: Saints -2.5Moneyline: Saints (-151), Falcons (+127)Total: 48.5Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets: