Week 1 college football predictions for Kalshi, Polymarket, Underdog: LSU vs. Clemson on Saturday

This page may contain affiliate links. If you click and sign up, make a deposit, or place a wager, we may earn a commission at no additional cost to you. SportsLine's advanced model has locked in its Week 1 college football predictions from 10,000 simulations Sep 5, 2026 at 9:52 am ET • 6 min read The Week 1 college football schedule continues throughout Labor Day weekend, with must-see matchups including Oregon vs. Boise State, Baylor vs. Auburn, Clemson vs. LSU, Notre Dame vs. Wisconsin and Louisville vs. Notre Dame. The only Top 25 matchup this week happens when No. 24 Louisville squares off against No. 9 Ole Miss at Nissan Stadium in Nashville on Sunday at 7:30 p.m. ET. Claim the newest Kalshi promo code CBSSPORTS, trade $25, and get $25 in trading bonus credits:The updated Week 1 college football prediction market prices are listed below, and SportsLine's advanced computer model has all the college football trading advice and CFB predictions you need to make the best Week 1 college football trades now.The SportsLine Projection Model, which simulates every FBS game 10,000 times, has turned its attention to the latest college football prediction markets and locked in predictions for every CFB matchup. You can also learn how to trade prediction markets and see the latest prediction markets legal states before locking in your college football predictions. Claim the Underdog Predict promo code CBS and get up to $1,000 in bonus funds here:Week 1 college football prediction marketsLSU ($0.77) vs. Clemson ($0.23)LSU will kick off its first season under new head coach Lane Kiffin against Clemson in Baton Rouge on Saturday. Kiffin led Ole Miss to its first College Football Playoff berth before accepting the position at LSU, forcing him to miss the postseason. LSU will start former Arizona State quarterback Sam Levitt, who threw for 1,628 yards, 10 touchdowns and three interceptions while being limited to seven games due to injuries in 2025. LSU's passing attack will also feature junior tight end Trey'Dez Green, who recorded 33 receptions for 433 yards and seven touchdowns last season. Clemson will start redshirt junior Christopher Vizzina at quarterback following Cade Klubnik's departure. Vizzina threw for 406 yards, four touchdowns, and one interception on 45 of 71 passing in five games last season, which included making one start in Klubnik's absence last October.LSU is trading at $0.77 to win at home, while Clemson is trading at $0.23 at Kalshi. SportsLine is projecting LSU to win, 31-18, on Saturday. Claim the newest Kalshi promo code CBSSPORTS, trade $25, and get $25 in trading bonus credits:Baylor ($0.28) vs. Auburn ($0.72)Auburn will kick off its first season under head coach Alex Golesh with a home game against Baylor on Saturday. Golesh, who went 23-15 in three seasons at South Florida, will take over a team that went 5-7 (1-7 SEC) in 2025. Former USF quarterback Byrum Brown followed his head coach to Auburn after throwing for 7,690 yards, 61 touchdowns and 19 interceptions in four seasons in Tampa, including 3,158 yards, 28 touchdowns and seven interceptions in 2025. Auburn ranked 10th among SEC teams in total offense (373.9 yards per game), 11th in scoring offense (26.8 points per game), seventh in total defense (329.2 yards allowed per game) and scoring defense (20.7 points allowed per game) last season. Baylor finished the 2025 season with a 5-7 (3-6 Big 12) record. The Bears will start former Florida quarterback DJ Lagway, who threw for 2,264 yards, 16 touchdowns, and an SEC-worst 14 interceptions, in Week 1. Baylor ranked third among Big 12 teams in total offense (451.1 yards per game), fifth in scoring offense (31.1 points per game), 12th in total defense (392.1 yards allowed per game) and 15th in scoring defense (32.6 points allowed per game) in 2025.Auburn is trading at $0.72 to win at home, while Baylor is trading at $0.28 at Polymarket. SportsLine is predicting Auburn to beat Baylor, 36-23, on Saturday. Trade on college football here with the Polymarket promo code CBSSPORTS and get a $50 bonus after a $10 deposit:Louisville ($0.29) vs. Ole Miss ($0.71)Louisville will face Ole Miss at Nissan Stadium in Nashville on Sunday evening. The Cardinals finished their third season under head coach Jeff Brohm with a 9-4 (4-4 ACC) record in 2025, which included winning their final regular season game against Kentucky and the Boca Raton Bowl against Toledo. Louisville will start Lincoln Kienholz at quarterback, making him the fourth transfer player to begin the season under center in four years. Kienholz spent three seasons at Ohio State behind Kyle McCord, Will Howard and Julian Sayin, throwing for 139 yards and one touchdown on 11 of 14 passing in seven appearances last season.Ole Miss is coming off its best season of the modern era, going 13-2 (7-1 SEC) and making its first College Football Playoff appearance. Pete Golding was named permanent head coach after taking over for a departing Lane Kiffin during the playoffs, which included a Fiesta Bowl loss to Miami in the semifinal.Ole Miss quarterback Trinidad Chambliss threw for 3,937 yards, the most among SEC quarterbacks, 22 touchdowns and three interceptions on 294 of 445 passing, while also recording 527 yards and eight touchdowns on 133 rushing attempts. Ole Miss is trading at $0.71 to win, while Louisville is trading at $0.29 at Kalshi. SportsLine is projecting the Rebels to win, 33-22, on Sunday. Claim the newest Kalshi promo code CBSSPORTS, trade $25, and get $25 in trading bonus credits:Wisconsin ($0.09) vs. Notre Dame ($0.92)Wisconsin will face Notre Dame at Lambeau Field in Green Bay on Sunday night. The Badgers finished their third season under head coach Luke Fickell with a 4-8 (2-7 Big Ten) record in 2025. Wisconsin will start former Old Dominion quarterback Colton Joseph in Week 1. Joseph threw for 4,251 yards, 32 touchdowns and 15 interceptions on 306 of 512 passing during his first two collegiate seasons. The Badgers ranked last among Big Ten teams in total offense (253.1 yards per game) and scoring offense (12.8 points per game), as well as seventh in total defense (323.5 yards allowed per game) and scoring defense (21.6 points allowed per game).Notre Dame finished 2025 with a 10-2 record, withdrawing from consideration for other bowl games after missing the College Football Playoff, after making the National Championship Game the previous season. Quarterback C.J. Carr threw for 2,741 yards, 24 touchdowns and six interceptions on 195 of 293 passing while starting in all 12 games as a redshirt sophomore. Notre Dame will look to replace running backs Jeremiyah Love and Jadarian Price, with junior Aneyas Williams expected to carry the load. Williams recorded 224 yards and five touchdowns on 24 rushing attempts in 2025. Notre Dame is trading at $0.92 to win, while Wisconsin is trading at $0.29 at Kalshi. SportsLine is projecting the Fighting Irish to win, 35-13, on Sunday. Trade on college football here with the Polymarket promo code CBSSPORTS and get a $50 bonus after a $10 deposit:Week 1 college football prediction market pricesGamePriceMarketEast Carolina vs. AlabamaEast Carolina $0.03, Alabama $0.98Trade on CFB at KalshiNorth Texas vs. IndianaNorth Texas $0.02, Indiana $0.99Trade on CFB at PolymarketOregon State vs. HoustonOregon State $0.08, Houston $0.93Trade on CFB at Underdog PredictBall State vs. Ohio StateBall State $0.01, Ohio State $0.99Trade on CFB at KalshiTennessee State vs. GeorgiaTSU $0.01, Georgia $0.99Trade on CFB at PolymarketBoise State vs. OregonBoise State $0.06, Oregon $0.95Trade on CFB at Underdog PredictFurman vs. TennesseeFurman $0.02, Tennessee $0.98Trade on CFB at KalshiMarshall vs. Penn StateMarshall $0.06, Penn State $0.95Trade on CFB at PolymarketTexas State vs. TexasTexas State $0.03, Texas $0.99Trade on CFB at Underdog PredictMissouri State vs. Texas A&MMissouri State $0.02, Texas A&M $0.99Trade on CFB at KalshiClemson vs. LSUClemson $0.23, LSU $0.78Trade on CFB at PolymarketWestern Michigan vs. MichiganWestern Michigan $0.04, Michigan $0.96Trade on CFB at Underdog PredictLouisville vs. Ole MissLouisville $0.29, Ole Miss $0.72Trade on CFB at KalshiWisconsin vs. Notre DameWisconsin $0.08, Notre Dame $0.93Trade on CFB at PolymarketSMU vs. Florida StateSMU $0.62, FSU $0.40Trade on CFB at Underdog Predict