Tumor Debulking Plus Chemotherapy for Multiorgan Metastatic Colorectal Cancer

To the Editor The ORCHESTRA trial addressed the evolving role of local therapy in metastatic colorectal cancer (mCRC). The authors should be commended for their rigorous evaluation of debulking in this challenging setting. The study required that patients have metastases in at least 2 different organs. However, patients had metastatic sites with very different prognoses (eg, lungs, bone, peritoneum). In such widely disseminated disease, progression of the less favorable site inevitably determine...