The Pragmatic Clinical Trial

What makes a clinical trial a pragmatic trial? Since the concept of pragmatic trial research was introduced nearly 60 years ago, this label has been applied and interpreted beyond its original meaning. Pragmatic trials were once proposed as alternatives to explanatory studies aimed at establishing the biophysiological effects of medical therapies, often in artificial settings, in narrow patient populations, or in comparison with alternatives that did not exist in routine care. Pragmatic trials w...