STAT+: Roivant lung disease drug hits mid-stage study goals

Company says it was pleasantly surprised by magnitude of results Adobe Adam Feuerstein is a senior writer and biotech columnist, reporting on the crossroads of drug development, business, Wall Street, and biotechnology. He is also a co-host of the weekly biotech podcast The Readout Loud and author of the newsletter Adam’s Biotech Scorecard. You can reach Adam on Signal at stataf.54. Roivant said Tuesday an experimental drug for a type of pulmonary hypertension achieved the goals of a mid-stage study — positive results that could open up a new way to treat the serious lung disease and bolster the biotech company’s financial health with a second blockbuster medicine. In the 16-week Phase 2 study, Roivant said, its drug mosliciguat achieved a statistically significant 56% reduction compared to placebo in pulmonary vascular resistance — a measure of blood pressure and flow within the artery that connects the right side of the heart to the lungs. Key 16-week secondary endpoints of the study were also met with statistical significance. Mosliciguat showed a 35-meter, placebo-adjusted improvement in six-minute walk distance and a 53% placebo-adjusted reduction in NT-proBNP, a blood-based marker of heart failure. STAT+ Exclusive Story Already have an account? Log in This article is exclusive to STAT+ subscribers Unlock this article — plus daily coverage and analysis of the biotech sector — by subscribing to STAT+. Already have an account? Log in View All Plans To read the rest of this story subscribe to STAT+. Subscribe Adam Feuerstein is a senior writer and biotech columnist, reporting on the crossroads of drug development, business, Wall Street, and biotechnology. He is also a co-host of the weekly biotech podcast The Readout Loud and author of the newsletter Adam’s Biotech Scorecard. You can reach Adam on Signal at stataf.54.