Review of Obesity and Cancer—Reply

In Reply We thank Dr Huang and colleagues for their interest in our translational science Review on obesity and cancer. They submit that hepatocarcinogenesis is less attributable to the mechanisms disrupted by obesity and more related to chronic metabolic liver injury—including steatosis, inflammatory activity, insulin resistance, and fibrosis. Although we agree that fibrosis and cirrhosis represent important contributing factors to hepatocellular carcinoma risk that were beyond the scope of our...