Rates of Precipitated Withdrawal in a Trial of ED–Initiated Buprenorphine for Opioid Use Disorder—Reply

In Reply We appreciate the opportunity to respond to comments by Drs Morris and Adams related to the low rate of precipitated withdrawal (<1%) in our recently published article, noting that 40% of the study patients had baseline urine toxicology positive for buprenorphine. We agree with Morris and Adams that even if all participants with buprenorphine-positive urine were excluded, the rate of precipitated withdrawal would remain very low. Of note, 1 of the 14 patients with precipitated withdr...