Precision, Pragmatism, and Emerging Paradigms in Determining Kidney Filtration Function

Chronic kidney disease (CKD) is defined largely by glomerular filtration rate (GFR), a construct with broad clinical implications. Guidelines from Kidney Disease: Improving Global Outcomes categorize CKD stages in adults according to GFR thresholds and albuminuria to assess risk of kidney failure. These CKD categories help clinicians dose medications with a narrow therapeutic window (eg, chemotherapy, antimicrobials), screen for metabolic complications of kidney dysfunction, determine eligibilit...