Precision Immunotherapy, Community-Acquired Pneumonia, and Sepsis—Reply

In Reply We thank Drs Jean and Lai for their interest in the ImmunoSep study and for raising the question of the potential interaction between the use of corticosteroids and precision immunotherapy, a promising therapeutic area in sepsis. The results of the ImmunoSep RCT showed that precision immunotherapy treatment for macrophage activation–like syndrome and sepsis-induced immunoparalysis may lead to significant early improvement of organ function. Precision treatment, however, should not be li...