Notre Dame vs. North Carolina prediction, odds, time: Week 5 college football picks by proven model

This page may contain affiliate links. If you click a link and sign up, make a deposit, place a wager, or make a trade, we may earn a commission at no additional cost to you. The SportsLine Projection Model has revealed its best bets for the Saturday matchup between the Notre Dame Fighting Irish vs. Bill Belichick and the UNC Tar Heels Oct 2, 2026 at 4:28 pm ET • 2 min read No. 3 Notre Dame has looked like a national title contender through four weeks, most recently crushing Purdue 49-10 on the road behind junior quarterback CJ Carr. The Fighting Irish (4-0) arrive at Kenan Stadium on Saturday as heavy favorites to extend their perfect start. North Carolina (2-1) enters with added preparation after a bye week following a 28-20 loss at Clemson in Week 3, with quarterback Billy Edwards Jr. directing the Tar Heels' offense under first-year head coach Bill Belichick, whose presence has generated significant buzz around the program entering this marquee home matchup. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10:Kickoff is set for noon ET at Kenan Stadium in Chapel Hill, N.C. The Fighting Irish are 20.5-point favorites in the latest Notre Dame vs. North Carolina odds, while the over/under is 46.5 points. Before making any Notre Dame vs. North Carolina picks, check out the Notre Dame vs. North Carolina predictions from the SportsLine Projection Model. Notre Dame vs. North Carolina oddsNotre Dame vs. North Carolina spreadNotre Dame -20.5Notre Dame vs. North Carolina over/under46.5 pointsNotre Dame vs. North Carolina money line Notre Dame -1639, UNC +1000Notre Dame vs. North Carolina picksSee picks at SportsLineNotre Dame vs. North Carolina streaming Fubo (Try for free) New to sports trading? Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55:Top Notre Dame vs. North Carolina predictionsAfter simulating Notre Dame vs. UNC 10,000 times, SportsLine model is going Over 46.5 points at betting apps. Notre Dame's last game went Over the total. North Carolina's last game against Clemson also went Over the total. CJ Carr and the Notre Dame offense have been dominant all season, averaging 42.3 points per game through four weeks, and the Fighting Irish have reached at least 49 points in every contest. Even with a Tar Heels defense that held Clemson in check in Week 3, the model projects Notre Dame's elite scoring ability to push the total past a modest number. The advanced model calls for 49 combined points to be scored. See the model's spread and money-line picks at SportsLine. How to make Notre Dame vs. North Carolina picksIn addition to going Over on the total, the model also says one side of the spread hits nearly 60% of the time. You can only get the pick at SportsLine. So who wins Notre Dame vs. UNC, and which side of the spread hits in nearly 60% of simulations? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that's on a 34-25 run on top-rated CFB picks, and find out.Why you should trust SportsLine's modelThe model simulates every FBS game 10,000 times. It enters Week 5 on a 32-24 run on all top-rated college football picks at betting sites, returning nearly $600 for $100 players. Anybody following its picks on college football betting sites could have seen strong returns.