New “Trojan horse” obesity drug supercharges weight loss in early tests

Researchers have created a next-generation obesity drug that works like a “Trojan horse,” using GLP-1/GIP signals to slip a powerful metabolic enhancer directly into target cells. In mice, it outperformed existing treatments—curbing appetite, increasing weight loss, and improving blood sugar levels. Because the extra drug acts only where it’s needed, it can be used at much lower doses, potentially reducing side effects.