Indiana vs. Michigan prediction, odds, time: Week 8 college football picks from proven model

This page may contain affiliate links. If you click a link and sign up, make a deposit, place a wager, or make a trade, we may earn a commission at no additional cost to you. SportsLine's model revealed its best bets for Saturday's Big Ten showdown of the Indiana Hoosiers vs. Michigan Wolverines Oct 24, 2026 at 10:32 am ET • 2 min read No. 6 Indiana travels to Ann Arbor looking to reclaim momentum after the Hoosiers' 22-game winning streak came to an end last week against Ohio State. Indiana (6-1, 3-1 Big Ten) arrives as the defending national champion and Big Ten contender, but now faces a tough road environment at Michigan Stadium with conference title hopes still very much on the line. Michigan (4-2, 1-2 Big Ten) has struggled to find its footing, with Bryce Underwood benched in favor of Tommy Carr as the Wolverines fight to stay relevant in the Big Ten race. Michigan safety Rod Moore and defensive tackle Enow Etta are both listed as game-time decisions. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55:Kickoff is set for noon ET at Michigan Stadium in Ann Arbor, Mich. Indiana is a 7.5-point favorite in the latest Indiana vs. Michigan odds, with the over/under at 41.5. Before making any Indiana vs. Michigan picks, check out the Indiana vs. Michigan predictions from the SportsLine Projection Model. Indiana vs. Michigan oddsIndiana vs. Michigan spreadIndiana -7.5Indiana vs. Michigan over/under42.5 pointsIndiana vs. Michigan money line Indiana -294, Michigan +250Indiana vs. Michigan picksSee picks at SportsLineIndiana vs. Michigan streaming Fubo (Try for free) Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10:Top Indiana vs. Michigan predictionsAfter simulating Indiana vs. Michigan 10,000 times, SportsLine model is going Over 42.5 points at betting apps. The defending champion Hoosiers have been generating consistent offensive production under quarterback Josh Hoover all season, and despite the loss to Ohio State that snapped Indiana's winning streak, the offense still showed enough output to push the total past a relatively modest line. Michigan has also shown a willingness to put points on the board in its wins this season, and with Tommy Carr stepping in at quarterback, both offenses should generate enough scoring to push past a 42.5-point total in a high-stakes Big Ten showdown.The model is projecting 43 combined points as the Over hits 54% of the time. See the model's spread and money-line picks at SportsLine. How to make Indiana vs. Michigan picksIn addition to going Over on the total, the model also says one side of the spread hits in well over 50% of simulations. You can only get the pick at SportsLine. So who wins Indiana vs. Michigan, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that's on a 59-49 run on top-rated CFB picks, and find out.Why you should trust SportsLine's modelSportsLine's model simulates every FBS game 10,000 times. It enters Week 8 on a 59-49 run on all top-rated college football picks at betting sites, returning more than $400 for $100 players. Anybody following its picks on college football betting sites could have seen strong returns.