Fantasy football Week 6 Start 'Em & Sit 'Em: Jordan Love builds on breakout Week 5

This page may contain affiliate links. If you click a link and sign up, make a deposit, place a wager, or make a trade, we may earn a commission at no additional cost to you. With four teams on a bye and stars like Justin Jefferson and Jahmyr Gibbs unavailable, here are the start, sit and sleeper calls to navigate the toughest lineup decisions of the season Oct 14, 2026 at 8:37 pm ET • 2 min read Welcome to Week 6, which is the most challenging scoring period so far this season. That's because it's the first week with four teams on a bye, and we have plenty of stars missing from Cincinnati, Detroit, Miami and Minnesota. At quarterback, we're down two must-start players in Joe Burrow and Jared Goff. The running backs missing are Jahmyr Gibbs, Chase Brown, Aaron Jones and Ollie Gordon II. The receiver corps is decimated, with Ja'Marr Chase, Tee Higgins, Amon-Ra St. Brown, Jameson Williams, Justin Jefferson, and Malik Washington on a bye. And we don't have Sam LaPorta, Mike Gesicki or T.J. Hockenson. It was already tough for some Fantasy managers to fill out a starting lineup because of the injuries, but now it's even more challenging in Week 6. But that's why you're here. We've got you covered with all the starts, sits, and sleepers you need to win in Week 6. And don't be surprised when players like Dameon Pierce, Germie Bernard and Kendrick Bourne help you earn a victory. It's about to get crazy in a lot of Fantasy leagues with four teams on a bye. So let's make sure those lineups are ready to go. Pick NFL at Underdog Fantasy, where new users who play $5 now get $100 in site credits with promo code CBSSPORTS2 in select states. Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline START 'EM & SIT 'EM Running Backs Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline Chiefs (vs. LAC)The Chargers could be without Ladd McConkey (foot), Quentin Johnston (chest) and Tre Harris (hamstring) in Week 6 against the Chiefs, who are coming off a bye. The Chargers also have a makeshift offensive line due to injuries and have scored 17 points or less in four of five games. Justin Herbert has also been sacked nine times in his past two games against Seattle and Denver, and the Chargers have four fumbles and three interceptions over that span. This should be a big week for the Chiefs DST. Projections powered by Sportsline Ravens (at CLE)49ers (vs. WAS)Colts (vs. TEN) Projections powered by Sportsline Jaguars (vs. HOU) I thought the Jaguars' DST had a chance to be dominant in Week 5 against Philadelphia, but Jacksonville managed just one sack and no turnovers, even though the Eagles scored just 17 points. The Jaguars have allowed 20 points or less in every game this season, but the Texans have scored 56 points in the past two games against Dallas and Tennessee. Houston hasn't had a turnover in four games in a row, and C.J. Stroud has been sacked just seven times in his past three outings. Projections powered by Sportsline Projections powered by Sportsline Projections powered by Sportsline