Defining Amyloid Positivity on the Centiloid Scale

Amyloid positron emission tomography (PET) plays a central role in both Alzheimer disease research and clinical care by enabling in vivo detection of cerebral amyloid-β deposition, one of the core pathological features of this disease. Over the past 2 decades, amyloid PET has transformed understanding of the natural history of Alzheimer disease and has had a pivotal role in patient selection and as a secondary outcome for clinical trials—ultimately paving the way for US Food and Drug Administrat...