Deescalation, Discontinuation, and Deimplementation Trials

Deescalation, discontinuation, and deimplementation trials have emerged in multiple health care contexts in which interventions are suspected of being inappropriately used, applied beyond their evidence base, or continued after they cease to offer meaningful benefit. These studies examine whether and how doing less—such as decreasing medication dosages, discontinuing screening tests, or shortening treatment regimens—can yield superior or at least noninferior outcomes compared with continuing cur...