Amoxicillin-Clavulanate vs Amoxicillin for Sinusitis

To the Editor Dr Savage and colleagues reported no difference in treatment failure between standard-dose amoxicillin-clavulanate and amoxicillin among adults aged 18 to 64 years treated for outpatient acute sinusitis, whereas amoxicillin-clavulanate was associated with higher risks of yeast infection and Clostridioides difficile infection. These findings are important for antimicrobial stewardship and support narrower-spectrum therapy when antibiotics are indicated for uncomplicated acute sinusi...